Studying THE mechanisms regulating mammalian male germ cell development
We use mouse spermatogenesis as a model system to investigate mechanisms regulating cellular differentiation. The daily production of millions of male gametes (sperm) relies on the activity of a small spermatogonial stem cell population that produces committed progenitor spermatogonia that differentiate in response to retinoic acid. It is currently unclear how these mammalian spermatogonial fate decisions are regulated; however, they are critical for maintaining tissue homeostasis, as imbalances cause spermatogenesis defects that can lead to human testicular cancer or infertility.
East Carolina Heart Institute
115 Heart Drive
Office 4112, Mail Stop 743
Greenville, NC 27834
(252) 744-3433
geyerc@ecu.edu